2,6-disubstituted derivatives of 3-nitropyrazines useful as adju

Details 2,6-disubstituted derivatives of 3-nitropyrazines useful as adju 2,6-disubstituted derivatives of 3-nitropyrazines useful as adju

1985-01-16

1986-09-02

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544336, 544409, 544407, C07D24116, C07D24124, A61K 31495

Patent

active

046096590

ABSTRACT:
2,6-Disubstituted derivatives of 3-nitropyrazine are disclosed to have activity in increasing the sensitivity of tumor cells to radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.

REFERENCES:
patent: 3541093 (1970-11-01), Tull et al.
patent: 3660397 (1972-05-01), Jones et al.
patent: 4414215 (1983-11-01), Hartmann
patent: 4416882 (1983-11-01), Hartmann
patent: 4418062 (1983-11-01), Hartmann
Derwent Abstract 70-15335R, Derwent Class B02, "5-Substd-Amino-6-Chloro(1H)Imidazo(4,5-6)Pyrazine-2-ones . . . ".
Hartman, et al, Mutation Research, 117, (1983), pp. 271-277.

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