2,6-disubstituted-5-cyano-4-pyrimidinyloxyacetic acid aldose red

Details 2,6-disubstituted-5-cyano-4-pyrimidinyloxyacetic acid aldose red 2,6-disubstituted-5-cyano-4-pyrimidinyloxyacetic acid aldose red

1987-06-12

1988-11-22

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544319, A61K 31505, C07D23902

Patent

active

047866403

ABSTRACT:
Disclosed herein are 2,6-disubstituted-5-cyano-4-pyrimidinyloxyacetic acids and pharmaceutically acceptable salts thereof and methods of their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

REFERENCES:
patent: 4234587 (1980-11-01), Maurer et al.
patent: 4505910 (1985-03-01), Bagli
patent: 4568693 (1986-02-01), Sestanj
patent: 4617393 (1986-10-01), Bagli
Noller, Textbook of Organic Chemistry, 3rd edition, W. B. Saunders Co., Philadelphia, 1966, pp. 139, 173.
Wolff, Burger's Medicinal Chemistry, 4th Ed., Part II, 1979, John Wiley & Sons, New York, pp. 1049-1057.

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