2,6-dimethyl-8.alpha.-pivaloylamino-9,10-didehydro-ergoline

Details 2,6-dimethyl-8.alpha.-pivaloylamino-9,10-didehydro-ergoline 2,6-dimethyl-8.alpha.-pivaloylamino-9,10-didehydro-ergoline

1987-01-12

1988-12-13

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 68, A61K 3148, C07D45712

Patent

active

047911158

ABSTRACT:
Compounds of formula I ##STR1## wherein R.sub.1 is hydrogen or C.sub.1-4 alkyl, R.sub.2 is hydrogen, chlorine, bromine or methyl, R.sub.3 is C.sub.1-5 alkyl or C.sub.3-5 alkenyl and R.sub.4 is C.sub.1-7 alkyl; C.sub.3-7 cycloalkyl; adamantyl; or optionally substituted phenyl, are useful as neuroleptic agents and PRL secretion inhibitors.

REFERENCES:
patent: 3218323 (1916-11-01), Hofmann et al.
patent: 4348391 (1982-09-01), Stutz et al.
patent: 4448392 (1982-09-01), Fehr et al.
Salvadi et al., CA 103-32119g.
Cider et al., CA 87-177456a.
Stuetz et al., CA 93-46946m.
Fehr et al., CA 98-54276m.
Stuetz et al., CA 98-198513j.
Haffer et al., CA 99-158703k.
Haefliger, CA 104-130106r.
Stuetz et al., CA 84-165094f.

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