2,6-Dimethyl-3,5-bis-(1-adamantylhydr oxycarbonyl)-4-(2-difluoro

Details 2,6-Dimethyl-3,5-bis-(1-adamantylhydr oxycarbonyl)-4-(2-difluoro 2,6-Dimethyl-3,5-bis-(1-adamantylhydr oxycarbonyl)-4-(2-difluoro

1983-04-19

1984-12-11

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424266, 546321, C07D21190

Patent

active

044879326

ABSTRACT:
A compound 2,6-dimethyl-3,5-bis-(1-adamantylhydroxycarbonyl)-4-(2-difluoromethoxyphen yl)-1,4-dihydropyridine of the formula ##STR1## is proposed. Said compound possesses antianginal activity.

REFERENCES:
Bossert F., et al: Dihydropyridine, eine neue Gruppe stark wirksamer Coronartherapeutica.-Naturwissenschafter, 1971, Bd.58, H.11, S.578.
Kastron V.V., et al.: 2,6-dimethyl-3,5-dicarbomethoxy-4-/o-difluoromethoxyphenyl/-1,4-dihydropyr idine Possessing a Marked Hypotensive Activity and Affecting Functions of Vegetative Nervous System, USSR Author's Certificate Bo. 704610/1979/, Discoveries, Inventions, Industrial Designs, Trademarks, 1979, No. 48, p. 88.
Kastron V. V., et al.: Synthesis and Pharmacological Activity of 4-aryl 1, 4-dihydropyridines, -Chemo-Pharmaceutical J., 1982, vol. 16, No. 11, pp. 1322-1329.

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