Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-06-24
2008-09-09
Aulakh, Charanjit S (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S194000, C546S268100, C514S336000
Reexamination Certificate
active
07423051
ABSTRACT:
Novel 2,6-diaminopyridine derivatives of formulawherein R1and R2are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.
REFERENCES:
patent: 6262096 (2001-07-01), Kim et al.
patent: 2003/0220326 (2003-11-01), Chong et al.
patent: WO 99/21845 (1999-05-01), None
patent: WO 01/19825 (2001-03-01), None
patent: WO 01/38315 (2001-05-01), None
patent: WO 01/79198 (2001-10-01), None
patent: WO 2004/074283 (2004-09-01), None
patent: WO 2005/051387 (2005-06-01), None
V. Mesguiche, et al., Bioorganic & Medicinal Chemistry Letters, vol. 13, pp. 217-222 (2003), XP002356484.
Sielecki T., et al., J. Med. Chem., 2000, vol. 43, pp. 1-18.
Lin, R. et al., Bioorganic & Medicinal Chemistry Letters, 2005, vol. 15(9) pp. 2221-2224.
Lin, R. et al., Journal of Medicinal Chemistry Letters, 2005, pp. A-D.
Harris, W. & Wilkinson, S., Emerging Drugs, 2000, vol. 5, pp. 287-297.
Dumas, J., Exp. Opin. Ther. Patents, 2001, vol. 11, pp. 405-429.
Bartkovitz David Joseph
Chu Xin-Jie
Lovey Allen John
Wovkulich Peter Michael
Aulakh Charanjit S
Hoffmann-La Roche Inc.
Johnston George W.
Rocha-Tramaloni Patricia S.
LandOfFree
2,6-diaminopyridine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2,6-diaminopyridine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,6-diaminopyridine derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3990094