2,6-diamino-heptandedioic acids

Details 2,6-diamino-heptandedioic acids 2,6-diamino-heptandedioic acids

1993-04-27

1994-03-22

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514541, 562565, 560169, A61K 31195, A61K 3124, C07C22900

Patent

active

052965015

ABSTRACT:
A compound selected from the group consisting of a compound of the formula ##STR1## wherein the dotted lines indicate an optionally endo or exo double bond, Y is selected from the group consisting of alkyl, alkenyl and alkynyl of 2 to 18 carbon atoms and alkyl of 1 to 18 carbon atoms substituted with at least one halogen, X, X' and X.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms, aryl of 6 to 14 carbon atoms, aralkyl of 7 to 18 carbon atoms, acyl of a fatty acid and acyl of an .alpha. or .omega.-amino acid, n and/or n.sub.1 is 1 and R and/or R.sub.1 is the remainder of an amine or an .alpha. or .omega.-amino acid or n and/or n.sub.1 is 2 and R and R.sub.1 are selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, aryl of 6 to 14 carbon atoms, aralkyl of 7 to 18 carbon atoms and ##STR2## R.sub.2 is alkyl of 1 to 8 carbon atoms or aryl of 6 to 14 carbon atoms and their non-toxic, pharmaceutically acceptable salts with acids or bases having antibacterial properties.

REFERENCES:
Agouridas et al., Chem Abst., (Dec. 5, 1985), vol. 105, 173044g, "Diaminopimelic acid derivatives", (Fr. Dewande FR 2,566,410).
Givodeau et al., Chem Abst., (1986), vol. 104, 2076372, "The Lysine Pathway . . . ", (J. Med. Chem., 1986, 29(6), 1023-30).

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