2,6-Diamino-1,4-dihydropyridine-3,5-dicarboxylic acid esters use

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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424258, 424263, A61K 31455

Patent

active

039594742

ABSTRACT:
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2,6-diamino-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an amidine with either an aldehyde or an ylidenecyanoacetoacetic acid ester.

REFERENCES:
patent: 3708489 (1973-01-01), Rucker et al.
patent: 3773773 (1973-11-01), Bossert
patent: 3775422 (1973-11-01), Bossert

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