2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine and a process

Details 2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine and a process 2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine and a process

1987-08-24

1988-08-16

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21355

Patent

active

047646136

ABSTRACT:
The invention relates to the novel 2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine of the formula (I) ##STR1## as well as a process for the preparation of this compound, which is a useful intermediate in the preparation of the anti-atherosclerotic 2,6-bis(hydroxymethyl)pyridine bis(N-methylcarbamate) (pyridinolcarbamate) and other drugs.
According to the invention, the compound of the formula (I) is prepared by reacting 2,6-bis(hydroxymethyl)pyridine of the formula (II) ##STR2## with chloromethyl chloroformate of the formula (III) ##STR3## in a polar-aprotic, water-immiscible organic solvent, in the presence of a basic substance between about -30.degree. C. and +10.degree. C.

REFERENCES:
Morrison et al., Org. Chem., 3rd Ed., pp. 456-457 (1978).

Affiliated with

Also associated with

Rating

2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine and a process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine and a process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine and a process will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-601422