Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-08-08
1998-11-17
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5462764, 5462784, A01N 4340, C07D40100
Patent
active
058377190
ABSTRACT:
The present invention addresses 2, 5-substituted aryl pyrroles of the formula: ##STR1## or a pharmaceutically acceptable salts thereof, as well as compositions containing such compounds and methods of treatment. The compounds are useful for treating Cytokine mediated diseases, which refers to diseases or conditions in which excessive or unregulated production or activity of one or more cytokines occurs. Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and Tumor Necrosis Factor (TNF) are cytokines which are involved in immunoregulation and other physiological conditions, such as inflammation. The compounds also have glucagon antagonist activity.
REFERENCES:
patent: 4267184 (1981-05-01), Cherkofsky
patent: 5286742 (1994-02-01), Henegar et al.
patent: 5442060 (1995-08-01), Jikihara et al.
patent: 5502051 (1996-03-01), Scharfenberg et al.
Heterocycles, vol. 35, No. 2, pp. 1171-1184 (1993), by Konakahara, et al.
Journal of Heterocyclic Chemistry, vol. 26, No. 2, pp. 489-492 (1989), by Silverstri, et al.
Journal of Heterocyclic Chemistry, vol. 29, No. 7, pp. 1847-1850 (1992) by Silvestri, et al.
Journal of the Chemical Society, J.C.S. Perkin 1, vol. 10, pp. 2642-2646 (1981), by Petruso, et al.
Konakahara et. al., "One-Pot Synthesis of Pyrroles . . . ", Heterocycles, vol. 35, No. 2, May 1993, pp. 1171-1184.
Chem. Ber., vol. 122, pp. 295-300 (1989), by F. Clerici, et al.
J. of Heter. Chem., vol. 28, pp. 793-796 (1991), by S. Petruso, et al.
de Laszlo Stephen E.
Liverton Nigel J.
Mantlo Nathan B.
Ponticello Gerald S.
Selnick Harold G.
Daniel Mark R.
Korsen Elliott
Merck & Co. , Inc.
Ngo Tamthom T.
Shah Mukund J.
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