2,',5'-phosphorothioate oligoadenylates and plant antiviral uses

Details 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses

1987-10-22

1990-05-15

Griffin, Ronald W.

Plant husbandry

Process

536 27, 536 28, 536 29, A01G 706, C07H 19167

Patent

active

049246240

ABSTRACT:
Optically active compounds of the formula ##STR1## wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internucleotide phosphorothioate linkages is of the Sp configuration possess increased antiviral activity and/or metabolic stability.

REFERENCES:
Lee et al., Biochemistry, vol 24(3), pp. 551-555, 1985.
Eppstein et al., J. Biol. Chem., vol. 261(13), pp. 5999-6003, 1986.
Lehningu, "Biochemistry, 2nd Ed.", Worth Publ., Inc., N.Y., N.Y., Jul. 1978, p. 315.
Schryver et al., Chem. Abstr., vol. 104; 199582k, 1986.
Schryver et al., Prog. Clin. Biol. Res., 202, (The 2-5A System: Molecular and Clinical Aspects of the Interferon-Regulated Pathway), 81-88, (1985).
Charubala et al., Chem. Abstr., 108: 204973c, 1988, (article published in 1987).
Pauwels et al., Chem. Abstr., 105: 151,227s, 1986.

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