2,5 OR 2,6-Disubstituted benzoxazoles

Details 2,5 OR 2,6-Disubstituted benzoxazoles 2,5 OR 2,6-Disubstituted benzoxazoles

1977-02-07

1978-07-11

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260307D, 260307C, C07D26354, C07D26358

Patent

active

041001680

ABSTRACT:
Benzoxazoles substituted in the 2-position with sulfhydryl or halogen and substituted in the 5- or 6-position with an acetic or propionic acid group or a salt or ester thereof or a nitrile convertible thereto useful as intermediates in the preparation of 5- or 6-Substituted benzoxazole propionic or acetic acid derivatives, substituted in the 2-position of the oxazole nucleus by a group of the formula AR.sup.4 wherein A is --CH.sub.2 --, --CO--, --CHOR--, or --NR--, wherein R is hydrogen, C.sub.1-6 alkyl or C.sub.2-7 acyl, and R.sup.4 is optionally substituted phenyl, useful as non-steroidal, non-narcotic, analgesic, antipyretic and anti-inflammatory agents.

REFERENCES:
patent: 4025637 (1977-05-01), Dunwell et al.

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