(2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof

Details (2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof (2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof

1981-04-10

1984-08-07

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 26, 536 27, A61K 3170, C07H 1512, C07H 1700

Patent

active

044643594

ABSTRACT:
3'-Deoxyadenosine 5'-triphosphate is oligomerized to form (2'-5')-oligo (3'-deoxyadenylate) by incubation with adenosine triphosphate: (2'-5')-oligo adenosine adenyl transferase, in the presence of an inert support carrying a double stranded polynucleotide. The (2'-5')-oligo (3'-deoxyadenylate) is digested with a suitable phosphatase to remove the terminal phosphate groups. The thus produced corresponding 3'-deoxyadenosine compound is an anti-viral material effective against Herpes Simplex infection and effective in inhibiting the transformation of cells infected with Epstein Barr virus.

REFERENCES:
patent: 2472130 (1949-06-01), Szent-Gyorgyi
patent: 3299043 (1967-01-01), Schramm et al.
patent: 3337530 (1967-08-01), Hanze
patent: 4000260 (1976-12-01), Prusoff et al.
patent: 4210746 (1980-07-01), Kerr et al.
patent: 4315001 (1982-02-01), Blough
patent: 4378352 (1983-03-01), Kimchi et al.
Cory et al., Biochimica et Biophysica Acta 103(4), pp. 646-653, (1954).

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