2-(5-Nitro-2-imidazolyl)-benzimidazoles

Details 2-(5-Nitro-2-imidazolyl)-benzimidazoles 2-(5-Nitro-2-imidazolyl)-benzimidazoles

1972-09-11

1977-10-11

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

260239B, 260268BC, 260268R, 2602936, 26029379, 548327, 548339, 26032647, 2603265L, 26032685, 2605705P, 42424855, 424250, 424267, 424273R, C07D40304, C07D40514

Patent

active

040534723

ABSTRACT:
2-(5-Nitro-2-imidazolyl)-benzimidazoles of the formula ##STR1## wherein R.sub.1 and R.sub.2 are H, halo, alkyl, alkoxy, nitro, trifluoromethyl or carboxy; A is H, alkyl, hydroxyalkyl or an ester thereof, haloalkyl, phenyl or a tertiary aminoalkyl group; and X is alkyl, hydroxyalkyl or an ester thereof, are antimicrobials, especially against Trichomonas vaginalis.

REFERENCES:
patent: 3309378 (1967-03-01), Dunn
patent: 3322783 (1967-05-01), Dunn
patent: 3478046 (1969-11-01), Sarett et al.
Rufer et al., Abandoned Application Ser. No. 29,705, pp. 1, 2, 3a, 3b, 13 & 14 (filed Apr. 17, 1970).
Dunn et al., J. Med. Chem., vol. 9, pp. 751-753 (1966).

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