Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-01-12
1976-11-30
Morgenstern, Norman
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
C07C 6360
Patent
active
039949680
ABSTRACT:
New compounds, 2-(6'-methoxynaphth-2'-yl)-propylene oxide, 2-(6'-methoxynaphth-2'-yl)proppionaldoxime, 2-hydroxy-2-(6'-methoxynaphth-2'-yl)-propionitrile, 2-(6'-methoxynaphth-2'-yl)acrylonitrile, 2-(6'-methoxynaphth-2'-yl)acrylic acid, the corresponding 5'-halo compounds and 2-(5'-halo-6'-methoxynaphth-2'-yl)propionaldehyde are useful intermediates in producing 2-(6'-methoxynaphth-2'-yl)propionic acid and the corresponding 5'-halo acids from 6-methoxy-2-acetylnaphthalene and the corresponding 5-halo compounds. The 2-propionic acids are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. The 2-propionaldehydes, obtained from the 2-acetyl compounds by way of the 2-propylene oxide, can be converted directly to the 2-propionic acids by way of the 2-propionaldoximes and the 2-priopionitriles or more directly by Jones oxidation. Alternatively the 2-acrylonitriles, obtained from the 2-acetyl compounds by way of the 2-hydroxy-2-propionitrile, can be converted to the 2-propionic acid by way of the 2-acrylic acid or 2-propionitrile.
REFERENCES:
patent: 2547123 (1951-04-01), Horeau et al.
patent: 3562336 (1971-02-01), Nelson
patent: 3626012 (1971-12-01), Fried et al.
Hirsch Joseph I.
Morgenstern Norman
Syntex Corporation
Walker William B.
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