2,5-disubstituted thiophenes: inhibitors of 5-lipoxygenase and i

Details 2,5-disubstituted thiophenes: inhibitors of 5-lipoxygenase and i 2,5-disubstituted thiophenes: inhibitors of 5-lipoxygenase and i

1997-03-04

1998-07-21

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514445, 549 63, 549 68, A61K 3138, C07D33336, C07D33342

Patent

active

057835977

ABSTRACT:
2,5-Disubstituted thiophene derivatives, and more particularly, to 2-aryloxy-5-alkansulfonamido-thiophenes of the general formula: ##STR1## Wherein, R.sub.2 is CF.sub.3, C.sub.1 -C.sub.10 alkyl, or phenyl;

REFERENCES:
patent: 3657432 (1972-04-01), Shen et al.
patent: 3963750 (1976-06-01), Goudie
patent: 4826868 (1989-05-01), Wachter et al.
patent: 4877809 (1989-10-01), Binder et al.
patent: 5164381 (1992-11-01), Wachter et al.
patent: 5242940 (1993-09-01), Wachter et al.
patent: 5298521 (1994-03-01), Ferro
patent: 5387602 (1995-02-01), Ferro
patent: 5403857 (1995-04-01), Edwards et al.
patent: 5501018 (1991-09-01), Appell et al.
patent: 5571821 (1996-11-01), Chan et al.
S. A. Beers et al., In Vitro and Invivo Pharmacology of RWJ 63556, a Potent, Orally Active 5-Lo Inhibitor with Specific COX-2 Ihnibitory Activity, Abstract #P49, Eight International Congress of the Inflammation Research Association, Oct. 28, 1996, Hersey PA.
Saida et al, "Preparation of Phenoxythiophene Derivatives", CA115:255987, 1991.

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