2,5-disubstituted pyrimidine derivatives

Details 2,5-disubstituted pyrimidine derivatives 2,5-disubstituted pyrimidine derivatives

2006-08-15

2006-08-15

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S212080, C514S221000, C514S234200, C514S234800, C514S249000, C514S256000, C540S524000, C540S543000, C540S556000, C544S071000, C544S122000, C544S328000, C544S333000

Reexamination Certificate

active

07091198

ABSTRACT:
The present invention relates to novel 2,5-disubstituted pyrimidine derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of central nervous system diseases.

REFERENCES:
patent: 19649460 (1998-05-01), None
patent: 19834045 (2000-02-01), None
patent: 19834047 (2000-02-01), None
patent: 19846514 (2000-04-01), None
Vippagunta et al., Crystalline Solids, Advanced Drug Delivery Reviews 48:3-26, 2001.
West, Solid Solutions, Solid State Chemistry and Its Applications, pp. 365, 1988.
Carvajal et al., Molecular Mechanism of cGMP-mediated Smooth Muscle Relaxation, Journal of Cellular Physiology, 184:409-420, 2000.
Yamashita et al., Mechanisms of Reduced Nitric Oxide/cGMP-mediated Vasorelaxation in Transgenic Mice Overexpressing Endothelial Nitric Oxide Synthase, Hypertension, 36:97-102, 2000.
Fisker et al., PubMed Abstract (J Endocrinol Invest. 22(5 Suppl):89-93) 1999.
Layzer, Degenerative Diseases of the Nervous System, Cecil Textbook of Medicine, 20th Edition, vol. 2, pp. 2050-2057, 1996.
Damasio, Alzheimer's Disease and the related dementias, Cecil Textbook of Medicine, 20th Edition, vol. 2, pp. 1992-1996, 1996.

Affiliated with

Also associated with

Rating

2,5-disubstituted pyrimidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2,5-disubstituted pyrimidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,5-disubstituted pyrimidine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3654834