2,5-dioxoimidazolidin-4-yl acetamines and analogues as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S389000, C514S444000, C546S290000, C548S318500, C549S059000

Reexamination Certificate

active

07354940

ABSTRACT:
The invention provides compounds of formula (I) in which L, X, Y, Z1, Z2, R1, R2, R3and G2have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds of the invention are inhibitors of metalloproteinase MMP12 and are among other things useful for the treatment of obstructive airways diseases, such as asthma and chronic obstructive pulmonary disease (COPD).

REFERENCES:
patent: 2745875 (1956-05-01), Ehrhart et al.
patent: 3452040 (1969-06-01), Langis
patent: 3529019 (1970-09-01), Suh et al.
patent: 3849574 (1974-11-01), Suh et al.
patent: 4241073 (1980-12-01), Jamieson et al.
patent: 4315031 (1982-02-01), Vincent et al.
patent: 5068187 (1991-11-01), Takeichi et al.
patent: 5246943 (1993-09-01), Blankley et al.
patent: 5308853 (1994-05-01), Hodges et al.
patent: 5521187 (1996-05-01), Freyne et al.
patent: 5804593 (1998-09-01), Warpehoski et al.
patent: 5919790 (1999-07-01), Allen et al.
patent: 5955435 (1999-09-01), Baxter et al.
patent: 6046214 (2000-04-01), Kristiansen et al.
patent: 6048841 (2000-04-01), Baxter et al.
patent: 6114361 (2000-09-01), Robinson et al.
patent: 6159995 (2000-12-01), Thorwart et al.
patent: 6166041 (2000-12-01), Cavalla et al.
patent: 6218418 (2001-04-01), Pevarello et al.
patent: 6268379 (2001-07-01), Xue et al.
patent: 6277987 (2001-08-01), Kukkola et al.
patent: 6291685 (2001-09-01), Junghans et al.
patent: 6329418 (2001-12-01), Cheng et al.
patent: 6339101 (2002-01-01), Ross et al.
patent: 6340691 (2002-01-01), Levin et al.
patent: 6429213 (2002-08-01), Xue et al.
patent: 6890915 (2005-05-01), Sheppeck et al.
patent: 6906053 (2005-06-01), Sheppeck et al.
patent: 7078424 (2006-07-01), Hamilton et al.
patent: 2002/0006920 (2002-01-01), Robinson et al.
patent: 2002/0028835 (2002-03-01), Hu et al.
patent: 2002/0065219 (2002-05-01), Naidu et al.
patent: 2002/0091107 (2002-07-01), Madar et al.
patent: 2003/0130273 (2003-07-01), Sheppeck et al.
patent: 2004/0106659 (2004-06-01), Af Rosenschold
patent: 2004/0110809 (2004-06-01), Lepisto et al.
patent: 2004/0116486 (2004-06-01), Lepisto et al.
patent: 2004/0127528 (2004-07-01), Eriksson et al.
patent: 2004/0138276 (2004-07-01), Eriksson et al.
patent: 2004/0147573 (2004-07-01), Eriksson et al.
patent: 2004/0152697 (2004-08-01), Chan et al.
patent: 2004/0209874 (2004-10-01), Sheppeck et al.
patent: 2005/0019994 (2005-01-01), Chang
patent: 2005/0026990 (2005-02-01), Eriksson et al.
patent: 2005/0171096 (2005-08-01), Sheppeck et al.
patent: 2005/0256176 (2005-11-01), Burrows et al.
patent: 2006/0063818 (2006-03-01), Burrows et al.
patent: 2006/0276524 (2006-12-01), Henriksson et al.
patent: 212617 (1986-08-01), None
patent: 0486280 (1991-11-01), None
patent: 0640594 (1995-03-01), None
patent: 0709375 (1995-10-01), None
patent: 1149843 (2001-10-01), None
patent: 1191024 (2002-03-01), None
patent: 1117616 (2003-04-01), None
patent: 02 74 1724 (2004-03-01), None
patent: WO95/14025 (1994-11-01), None
patent: WO 1996/27583 (1996-09-01), None
patent: WO98/50359 (1998-05-01), None
patent: WO99/06361 (1999-02-01), None
patent: WO99/42443 (1999-02-01), None
patent: WO99/24399 (1999-05-01), None
patent: WO 00/09103 (1999-08-01), None
patent: WO 00/35886 (1999-12-01), None
patent: WO99/62880 (1999-12-01), None
patent: WO 00/12477 (2000-03-01), None
patent: WO 00/12478 (2000-03-01), None
patent: WO 00/40577 (2000-07-01), None
patent: WO00/044770 (2000-08-01), None
patent: WO 00/75106 (2000-12-01), None
patent: WO 01/05756 (2001-01-01), None
patent: WO 01/12189 (2001-02-01), None
patent: WO 01/22363 (2001-03-01), None
patent: WO 01/34573 (2001-05-01), None
patent: WO 02/006232 (2002-01-01), None
patent: WO 02/014262 (2002-02-01), None
patent: WO 02/014354 (2002-02-01), None
patent: WO 02/020515 (2002-03-01), None
patent: WO 02/074749 (2002-09-01), None
patent: WO 02/074751 (2002-09-01), None
patent: WO 02/074752 (2002-09-01), None
patent: WO 02/074767 (2002-09-01), None
patent: WO 02074748 (2002-09-01), None
patent: WO 02074750 (2002-09-01), None
patent: WO 02/96426 (2002-12-01), None
patent: WO/02/096426 (2002-12-01), None
patent: WO 03/040098 (2003-05-01), None
patent: WO 2004/020415 (2004-03-01), None
patent: WO 2004/024060 (2004-03-01), None
patent: WO 2004/024698 (2004-03-01), None
patent: WO 2004/024718 (2004-03-01), None
patent: WO 2004/024721 (2004-03-01), None
patent: WO06/004532 (2006-01-01), None
patent: WO06/004533 (2006-01-01), None
Nicolet “Interpretation of the Dehydration of Acetylglutamic Acid by Means of Glutamylthiohydantion Derivatives” Journal of the American Chemical Society 1930, 1192-1195.
STN International, file CAPLUS, accession No. 1994:299315, Document No. 120:299315, Sakamoto, Shuichi et al., “Preparation of pyridylserine derivatives as psychotropics,” WO, A1, 9320053, 19931014, See CAS RN 154696-31-8, 154697-48-0.
STN International, file CAPLUS, accession No. 1997:644516, Batty, Craig et al. “Synthesis and exchange reaction of 5-alkyl-2oxo-6-thioxo-1,2,3,6-hexahydropyrimidine-4-carboxylic acids” 7 Journal of Heterocyclic Chemistry (1997), 34:3, 1355-1367.
STN International, file CAPLUS, accession No. 2002-640897, Gooding, Owen W. et al. “Use of Statistical Design of Experiments in the Optimization of Amide Synthesis Utilizing Polystryene- Supported N-Hydroxybenzotriazole Resin” & Journal of Combinatorial Chemistry (2002), 4(6), 576-583.
STN International, File CAPLUS, CAPLUS accession No. 1968:506154, Doc. No. 69:106154, Lora-Tamayo, J. et al.: “Potential anticancer agents, VI. Sulfonic analogs of aspartic acid”, & An. Quim. (1968), 64(6), 591-606.
STN International, File CAPLUS, CAPLUS accession No. 1974:463633, Doc. No. 81:63633, Blaha, Ludvik et al.: “5-Methyl-5-phenoxymethyl-hydantoins”, & CS 151744, B, 19731119.
STN International, File CAPLUS, CAPLUS accession No. 1988:631020, Doc No. 109:231020, Mitsui Toatsu Chemicals, Inc.: “Process for the preparation of 5-benzylhydantoins as intermediates for aromatic amino acids”; & JP, A2, 63079879, 19880409.
STN International, File CAPLUS, CAPLUS accession No. 1989:173366, Doc. No. 110:173366, Oh, Chang Hyun et al., “Synthesis of new hydantoin-3-acetic acid derivatives”, & Bull. Korean Chem. Soc. (1988), 9(4), 231-5.
STN International, File CAPLUS, CAPLUS accession No. 1990:138955, Doc. No. 112:138955, Crooks, Peter A. et al.: “Synthesis of 5-benzoyl-5-phenyl-and-5-(Phenylhydroxymethyl)-5-phenylhydantoins as potential anticonvulsants”; & J. Heterocycl. Chem. (1989), 26(4), 1113-17.
Whittaker et al. “Design and Therapeutic Application of Matrix Metalloproteinase Inhibitors.” Chem Rev. 99 (1999), pp. 2735-2776.
Aharony et al. “Pharmacological Characterization of a New Class of Nonpeptide Neurokimin A Antagonists that Demonstrate Species Selectivity.” J. Pharmacol. Exp. Ther. 274:3 (1995), pp. 1216-1221.
Aimoto et al. “Synthesis of Carriers of Differing Strokes Radius with Activated Acyl Groups for Use as Reagents in Labeling Membrane Proteins.” Journal of Biological Chemistry, vol. 256(10), pp. 5134-5143, 1981.
Chemical Abstracts, vol. 65, 1966, Abstract No. 13684 h, M. Lora-Tamayo et al.: “Potential anticancer agents. I. Glutamine sulfonate analogs”, & Anales Real Soc. Espan. Fis. Quim (Madrid), Ser. B. 62(2), 173-86.
Croce, P. et al. “Stereoselective aldol addition of a chirai glycine enloate synthon to heteroaromatic aldehydes.” Heterocycles, 52:3 (2000) pp. 1337-1344.
Knabe, J. “Razemate und enantiomere basisch substituierter 5-phenylhdantoine.” Pharmazie. 52:12 (1997) pp. 912-919.
Bright et al. “Monoclonal Antibodies as Surrogate Receptors in High Throughput Screen for Compounds that Enhance Insulin Sensitivity.” Life Sciences. 61:23 (1997), pp. 2305-2315.
Lora-Tamayo et al. “anticancerousos Potenciales.” An. Quim.

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