2,5-diketo-D-gluconic acid reductase

Details 2,5-diketo-D-gluconic acid reductase 2,5-diketo-D-gluconic acid reductase

1984-10-29

1988-05-31

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

435105, 435138, 435843, C12N 902, C12P 1902, C12P 760, C12R 115

Patent

active

047481226

ABSTRACT:
A novel reductase is produced from a microorganism which belongs to genus Corynebacterium and is useful as a catalyst which catalizes, in the presence of NADPH, reduction of 2, 5-diketo-D-gluconic acid or its salts to 2-keto-L-gulonate or the corresponding salts thereof. It also catalizes reduction of 5-keto-D-fructose to sorbose, in the presence of NADPH.

REFERENCES:
patent: 3922194 (1975-11-01), Sonoyama et al.
patent: 3959076 (1976-05-01), Sonoyama et al.
patent: 3963574 (1976-06-01), Sonoyama et al.
patent: 3998697 (1976-12-01), Sonoyama et al.
Fundamentals of Enzymology, 1982, pp. 15-43.
Chemical Abstracts, vol. 67, No. 23, dated Dec. 24, 1967, p. 9924, Abstract No. 105462P, entitled "5-Ketogluconic Acid Reductase", 1979.
2340 Agricultural and Biological Chemistry, vol. 43, No. 1, "Crystallization and Properties of 5-Keto-D-gluconate Reductase from Gluconobacter suboxydans.
"Production of 2-Keto-L-Gulonate, an Intermediate in L-Ascorbate Synthesis, by a Genetically Modified Erwinia herbicola by S. Anderson, et al., in Science, vol. 230, Oct. 1985, pp. 144-149.

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