[2,5-Dihydro 5-phenyl-2-oxo-3-furanyl]amines

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...


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540455, 540454, 540485, 540491, 540460, 540500, 544253, 544283, 546146, 546214, 548323, 548327, 548453, 548953, 549321, 514183, C07D41712, A61K 31395




The present invention relates to compounds of the formula ##STR1## wherein R.sub.c is carboxy, esterified carboxy or amidated carboxy; R.sub.2 is hydrogen or lower alkyl or joins with R.sub.a and R.sub.b and the atoms therebetween to form a fused ring ##STR2## and either R.sub.a is methyl and R.sub.b is ##STR3## or R.sub.2 and R.sub.b and the atoms therebetween form a group ##STR4## wherein R.sub.3 and R.sub.4 are either both hydrogen, or together are propylene, butylene, or with the two atoms to which they are attached form a benzene ring. Methods of manufacture and use thereof in the production of angiotensin converting enzyme inhibitors are disclosed.

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patent: 4473575 (1984-09-01), Watthey
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Slade et al., "Journal of Medicinal Chemistry", vol. 28, p. 1517 (1985).


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