[2,5-Dihydro 5-phenyl-2-oxo-3-furanyl]amines

Details [2,5-Dihydro 5-phenyl-2-oxo-3-furanyl]amines [2,5-Dihydro 5-phenyl-2-oxo-3-furanyl]amines

1988-09-27

1990-04-17

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540455, 540454, 540485, 540491, 540460, 540500, 544253, 544283, 546146, 546214, 548323, 548327, 548453, 548953, 549321, 514183, C07D41712, A61K 31395

Patent

active

049181874

ABSTRACT:
The present invention relates to compounds of the formula ##STR1## wherein R.sub.c is carboxy, esterified carboxy or amidated carboxy; R.sub.2 is hydrogen or lower alkyl or joins with R.sub.a and R.sub.b and the atoms therebetween to form a fused ring ##STR2## and either R.sub.a is methyl and R.sub.b is ##STR3## or R.sub.2 and R.sub.b and the atoms therebetween form a group ##STR4## wherein R.sub.3 and R.sub.4 are either both hydrogen, or together are propylene, butylene, or with the two atoms to which they are attached form a benzene ring. Methods of manufacture and use thereof in the production of angiotensin converting enzyme inhibitors are disclosed.

REFERENCES:
patent: 4410520 (1983-10-01), Watthey
patent: 4473575 (1984-09-01), Watthey
patent: 4725617 (1988-02-01), Fodor et al.
Baumrucker et al., "J. Org. Chem.", vol. 33, No. 10, Oct. 1968.
Morrison et al., Organic Chemistry, 3rd ed. (6/77).
Ben-Ishai et al., "Tetrahedron", vol. 33, pp. 1533-1542 (1977).
Meyer et al., "Journal of Organic Chem.", vol. 22, pp. 1560-1565 (1957).
Drugs of the Future, vol. 9, No. 5, pp. 317-319 (1984).
Slade et al., "Journal of Medicinal Chemistry", vol. 28, p. 1517 (1985).

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