2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

548336, C07D40712, A61K 31415

Patent

active

051149613

ABSTRACT:
The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein R.sup.4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group and at least one of the substituents at positions 3, 4 or 5 contains a heterocyclic, heteroaryl or substituted phenylthio moiety.

REFERENCES:
patent: 3769350 (1973-10-01), Perry et al.
patent: 4539332 (1985-09-01), Biftu et al.
patent: 4595693 (1986-05-01), Biftu et al.
patent: 4757084 (1988-07-01), Biftu et al.
patent: 4977146 (1990-12-01), Biftu
patent: 4996203 (1991-02-01), Biftu
patent: 5001123 (1991-03-01), Biftu
patent: 5010100 (1991-04-01), Biftu
patent: 5011847 (1991-04-01), Biftu
Chem. Abstracts vol. 42, Abstract 5836e (1948).
Chem. Abstracts vol. 79, Abstract 136925u (1973).
Chem. Abstracts vol. 81, Abstract 135662k (1974).
Chem. Abstracts vol. 83, Abstract 8676g (1975).
Chem. Abstracts vol. 86, Abstract 16468v (1977).
Chem. Abstracts vol. 90, Abstract 54746z (1979).
Chem. Abstracts vol. 96, Abstract 1225588a (1982).
Biftu, T., Hazra, G. B. Stevenson, R., and Williams, J. R., Synthesis of lignans, 2,3-diaroylbutanes J. Chem. Soc. pp. 1147-1150 (1978).
Biftu, T., Hazra, G. B. Stevenson, R., Synthesis of (+)-Deoxyschizandrin, J. Chem. Soc. pp. 2276-2281 (1979).
Hwang, S. B., Lam, M. H., Biftu, T., Beattie, T. R., Asghen, T. Y., Trans-2,5-bis-(3,4,5-trimethoxyphenyl) tetrahydrofuran, J. Biol. Chem. vol. 260, No. 29, pp. 15639-15645 (Dec. 1985).
Sarkanen, K. V. and Wallis, A. F. A., Oxidative Dimerization's of (E)- and (Z)-Isoeugenol (2-Methoxy-4-propenylphenol) and (E)- and (Z)-2,6-dimethoxy-4-propenyl-phenol, J. Chem. Soc., Perkin transactions, pp. 1869-1878 (1973).
Stevenson, R., Williams, J. R., Synthesis of Tetrahydrofuran lignans, (+)-Galbelgin and (+)-Grandisin, Tetrahedron, vol. 33, pp. 285-288 (1977).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonis will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2417663

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.