2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514255, 514318, 514341, 514342, 514343, 514336, 544124, 544360, 546194, 546278, 546280, 546281, 546283, C07D40504, C07D41312, A61K 3144, A61K 3155

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active

050011235

ABSTRACT:
The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein Ar is a pyridyl, a dimethoxy-pyridyl or dimethoxy-pyrazyl group, R.sup.4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group and at least one of the substituents at positions 3,4 or 5 contains a heterocyclic, heteroaryl or substituted phenylthio group.

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Sarkanen, K. V. and Wallis, A. F. A., Oxidative Dimerizations's of (E)- and (Z)-Isoeugenol (2-Methoxy-4-propenylphenol) and (E)- and (Z)-2,6-dimethoxy-4-propenyl-phenol, J. Chem. Soc., Perkin transactions, pp. 1869-1878 (1973).
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