Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-11-14
1985-09-03
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514333, 514336, 514422, 514444, 514471, 514473, 546256, 546283, 548517, 548518, 549 60, 549429, 549472, 549473, 549475, 549476, 549477, 549478, 549487, 549492, 549494, 549495, 549497, 549499, 549500, 549502, 549504, A61K 3134, C07D30706, C07D30712
Patent
active
045393320
ABSTRACT:
Analogs of 2,5-Diaryl tetrahydrofurans which were substituted or unsubstituted at 3,4-positions were prepared.
These compounds are found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and thereby useful in the treatment of various diseases or disorders mediated by the PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, adult respiratory distress syndrome, pain, and aggregation of platelets.
REFERENCES:
Yamakawa et al., Chemical Abstracts, vol. 79 (1973), 136925u.
Steckhan et al., Chemical Abstracts, vol. 81 (1974), 135662k.
Neudeck et al., Chemical Abstracts, vol. 83 (1975), 8976g.
Sato et al., Chemical Abstracts, vol. 96 (1982), 122588a.
Biftu et al., J. Chem. Soc., 1147 (1978).
Biftu et al., J. Chem. Soc. 2276 (1979).
Beattie Thomas R.
Biftu Tesfaye
Doebber Thomas W.
Hwang San-Bao
Shen Tsung-Ying
Cheng Theresa Y.
Merck & Co. , Inc.
Monaco Mario A.
Raymond Richard L.
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