2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonis

Details 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonis 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonis

1990-04-11

1990-12-11

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514461, 514471, 549218, 549491, 549496, 549500, 549501, 549502, C07D30712, C07D30714

Patent

active

049771469

ABSTRACT:
The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein R.sup.4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group, Y is an alkyl or substituted alkyl group, R.sup.6 is an alkyl or a substituted alkyl group and the substituents at positions 3, 4 or 5 are acyclic.

REFERENCES:
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patent: 4539332 (1985-09-01), Biftu et al.
patent: 4595693 (1986-05-01), Biftu et al.
patent: 4757084 (1988-07-01), Biftu et al.
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Chem. Abstracts, vol. 86, Abstract 1648v (1977).
Chem. Abstracts, vol. 90, Abstract 54764z (1979).
Chem. Abstracts, vol. 42. Abstract 5836e (1948).
Chem. Abstracts, vol. 79, Abstract 136925u (1973).
Chem. Abstracts, vol. 81, Abstract 135662k (1974).
Hwang, S. B., Lam, M. H., Biftu, T., Beattie, T. R., Asghen, T. Y., Trans-2,5-bis(3,4,5-trimethoxyphenyl) tetrahydrofuran, J. Biol. Chem, vol. 260, No. 29, pp. 15639-15645 (Dec. 1985).
Sarkanen, K. V. and Wallis, A. F. A., Oxidative Dimerization's of (E)-and (2)-Isoeugenol (2-Methoxy-4-propenylphenol) and (E)-(Z)-2,6-dimethoxy-4-propenyl-phenol, J. Chem. Soc., Perkin Transactions, pp. 1869-1878 (1973).
Stevenson, R., Williams, J. R., Synthesis of Tetrahydrofuran Lignans, (+)-Galbelgin and (+)-Grandisin, Tetrahedron, vol. 33, pp. 285-288 (1977).

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