2,5-anhydro-1,6-dihalo-1,6-dideoxy-D-mannitol

Details 2,5-anhydro-1,6-dihalo-1,6-dideoxy-D-mannitol 2,5-anhydro-1,6-dihalo-1,6-dideoxy-D-mannitol

1987-10-22

1989-10-03

Dixon, Jr., William R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514910, 536 11, 536122, A61K 31045

Patent

active

048717762

ABSTRACT:
A novel fructose analog is disclosed which has been found to modify the food intake of mammals. If administered during the diurnal fasting period, the mammals increase their food intakes. If administered during the diurnal feeding period, food intake is decreased. The compound is 2,5-anhydro-1,6-dihalo-1,6-dideoxy-D-mannitol, preferably 2,5-anhydro-1,6-dichloro-dideoxy-D-mannitol ("Charmitol").

REFERENCES:
patent: 4808626 (1989-02-01), Friedman
Kissileff, H. R. et al., "Physiology of the Control of Food Intake", Ann. Rev. Nutri., 2:371-418 (1982).
Russek, M., "Current Status of the Hepatostatic Theory of Food Intake Control", Appetite, 2:137-143 (1981).
Friedman, M. I. et al., "The Physiological Psychology of Hunger: A Physiological Perspective", Physiological Review, 83(6): 409-431 (1976).
Riquelme, P. T. et al., "Mechanism of Action of 2,5-Anhydro-D-Mannitol in Hepatocytes", Journal of Biological Chemistry, 259(8): 5115-5123 (Apr. 25, 1984).
Stevens, H. C. et al., "2,5-Anhydro Mannitol Inhibits Gluconeogenesis from Dihydroxyacetone in Rat Hepatocytes", Fed. Proc., 42, Part 2, Abstract No. 2384 (1983).
Stevens, H. C. et al., "2,5-Anhydro-D-Mannitol Inhibits Glycogenolysis in Isolated Rat Hepatocytes", Fed. Proc., 40, Part 1, Abstract 3479 (1981).
Hanson, R. L. et al., "Hypoglycemic Effect on 2,5-Anhydro-D-Mannitol", Fed. Proc., 42 (Part 1), Abstract No. 1453 (1983).
Raushel, F. M. et al., "The Substrate and Anomeric Specificity of the Fructokinase", Journal of Biological Chemistry, 248(23):8174-8177 (Dec. 10, 1973).
Riquelme, P. T. et al., "Inhibition by 2,5-Anhydromannitol of Glycolysis in Isolated Rat Hepatocytes and in Ehrlich Ascites Cells", Proc. Natl. Acad. Sci. U.S.A., 82:78-82 (Jan. 1985).
Riquelme, P. T. et al., "Regulation of Carbohydrate Metabolism by 2,5-Anhydro-D-Mannitol", Proc. Natl. Acad. Sci. U.S.A., 80:4301-4305 (Jul. 1983).
Hanson, R. L. et al., "Inhibition of Gluconeogenesis and Glycogenolysis by 2,5Anhdro-D-Mannitol", Journal of Biological Chemistry, 259(1):218-223 (Jan. 10, 1984).

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