2-, 5-, and 6-Substituted-1-carbadethiapen-2-em-3-carboxylic aci

Details 2-, 5-, and 6-Substituted-1-carbadethiapen-2-em-3-carboxylic aci 2-, 5-, and 6-Substituted-1-carbadethiapen-2-em-3-carboxylic aci

1979-07-25

1981-05-26

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

260239A, 2602452T, 42424852, 424250, 424263, 424267, 542413, 542416, 546157, 546200, 546272, 544 90, 544132, 544144, 544298, C07D48704, A61K 3140

Patent

active

042698731

ABSTRACT:
Disclosed are 2-, 5- and 6-substituted-1-carbadethiapen-2-em-3-carboxylic acids having the structure: ##STR1## wherein R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are, inter alia, independently selected from the group consisting of hydrogen, (R.sup.9 is not hydrogen), alkyl, alkenyl, aryl and aralkyl. Such compounds, as well as their pharmaceutically acceptable salt, ester and amide derivatives, are useful as antibiotics. Also disclosed are processes for the preparation of such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 4153714 (1979-05-01), Donsford
patent: 4181733 (1980-01-01), Christensen et al.
Derwent Abs. 33719B, (Eur. Patent App. 1628), (5/2/79).
Johnston et al., Heterocycles, vol. 9, No. 6, p. 791, (1978).

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