2,5,6-substituted N.sub.1 -alkylpyrimidines

Details 2,5,6-substituted N.sub.1 -alkylpyrimidines 2,5,6-substituted N.sub.1 -alkylpyrimidines

1987-08-06

1990-10-23

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544262, 544296, 544313, 544315, 544316, 544317, 544322, 544334, 544390, 546321, 546348, 548152, 548178, 548202, 548335, 548373, 564305, C07D23930, C07D23947, C07D23952

Patent

active

049653571

ABSTRACT:
The synthesis and application of N(1)-n-alkyl-pyrimidinium-salts are described. These surfactants have a very small critical micelle concentration (CMC) in the order of 10.sup.-5 -10.sup.-7 Mol/Liter. These N(1)-n-alkyl-pyrimidinium components have pharmacological activities and can act as antimetabolites.

REFERENCES:
patent: 4013643 (1977-03-01), Nysted
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Niculescu et al., Revue Roumaine de Biochimie 17, 1, 51-56 (1980).
Grier et al., Journal of Coating Technology 52, 671, 57-63 (1980).
El-Nakeeb, Arzneim-Forsch., 1976, 26(1), 14-20.
Bejan, Chem. Abst. 74-91574 g (1971), "Adsorption of Capillary-Active Substances on Ion-Exchange Resins".
El-Nakeeb, Chem. Abst. 84-100090 g (1976), "Development of an Agar-Diffusion Method for the Assay of Quaternary Ammonium Germicides".
Grier et al., Chem. Abst. 94-78268d (1981), "n-Dodecyl-Substituted Aminopyrimidium Salt Derivatives as Paint Film Antifungal Agents".
Niculescu et al., Chem. Abst. 95-57049 p (1981), "The Effect of Surfactants Upon Horseradish Peroxidase".

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