2,4 Pyrrolidinediones

Details 2,4 Pyrrolidinediones 2,4 Pyrrolidinediones

1976-10-15

1979-02-06

Tovar, Jose

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032644, 424274, C07D20740, A61K 3140

Patent

active

041384075

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: m is 1 or 2; n is 4 to 8; X is CO, protected CO, or CROH wherein R is hydrogen or C.sub.1-4 alkyl and wherein the OH moiety may be protected; R.sub.1 is hydrogen or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1 to 12 carbon atoms; R.sub.3 is hydroxy, or protected hydroxy; R.sub.2 and R.sub.4 are separately hydrogen, C.sub.1-9 alkyl, C.sub.5-8 cycloalkyl, C.sub.5-8 cycloalkyl-C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl, naphthyl, naphthyl C.sub.1-6 alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or nitro groups; or R.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; and salts thereof; except that when one of R.sub.2 and R.sub.4 is hydrogen or C.sub.1-4 alkyl when the other of R.sub.2 and R.sub.4 cannot be hydrogen or C.sub.1-9 alkyl; have useful pharmacological properties including antigastric secretion, bronchodilator and platelet aggregation inhibition activities.

REFERENCES:
patent: 3975399 (1976-08-01), DeFranco et al.
patent: 4003911 (1977-01-01), Scribner

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