2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido[2,3-d]pyrimidin-7...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S279000

Reexamination Certificate

active

07022711

ABSTRACT:
This invention provides antiangiogenic compounds of the Formula (I), which are useful for treating diseases, resulting from uncontrolled cellular proliferation such as cancer, atherosclerosis, rheumatoid arthritis, and psoriasis.

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PCT International Search Report PCT/US01/22881.
S. R. Klutchko, et al., “2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure-Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity”, J. Med. Chem., 1998, vol. 41, pp 3276-3292.
D. H. Boschelli, et al., “Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors”, J. Med. Chem., 1998, vol. 41, pp 4365-4377.
S. Trumpp-Kallmeyer, et al., “Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-d]pyrimidine Inhibitors”, J. Med. Chem., 1998, vol. 41, pp 1752-1763.
R. L. Panek, et al., In Vitro Pharmacological Characterization of PD 166285, a New Nanomolar Potent and Broadly Active Protein Tyrosine Kinase Inhibitor:, J. Pharmacol. Exp. Ther., 1997, vol. 283 No. 3, pp 1433-1444.

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