Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1978-04-24
1979-11-27
Rizzo, Nicholas S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
424270, C07D27704
Patent
active
041761200
ABSTRACT:
2-[4-(Polyhalo-2-hydroxy-2-propyl)anilino]-2-oxazolin-4-ones and the thiazolin-4-ones corresponding thereto, having useful anti-hypertensive properties, are disclosed herein. The compounds are prepared by reaction of the appropriate 4-(polyhalo-2-hydroxy-2-propyl)aniline with a .beta.-chloroethanoyl isocyanate or isothiocyanate and then cyclization of the resultant intermediate.
REFERENCES:
patent: 4071528 (1978-01-01), Dalton et al.
patent: 4081547 (1978-03-01), Neustadt
patent: 4103018 (1978-07-01), Neustadt et al.
Neustadt Bernard R.
Zampaglione Nicola
Eisen Bruce M.
King Mary S.
Renda Barbara L. Cowley
Rizzo Nicholas S.
Schering Corporation
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