2-(4-Phenylpiperazinylethyl) anilines

Details 2-(4-Phenylpiperazinylethyl) anilines 2-(4-Phenylpiperazinylethyl) anilines

1986-03-21

1987-05-26

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514253, 544377, 544398, 544402, A61K 31495

Patent

active

046686819

ABSTRACT:
This invention relates to 2-(4-phenylpiperazinylethyl)anilines, to methods for preparing them and to their uses in medical therapy.
These compounds have the following general formula ##STR1## wherein R.sub.1 represents one or more substituents selected from the group consisting of H, CH.sub.3, CF.sub.3, F, Cl, and OCH.sub.3 ; R.sub.2 and R.sub.3, which may be the same or different, and are selected from the group consisting of H and (C.sub.1 -C.sub.4) alkoxy, or R.sub.2 and R.sub.3 taken together can form a chain selected from the group consisting of --O-- (CH.sub.2).sub.n --O--, wherein n=1 or 2 and --O--CH.sub.2 --O--CH.sub.2 with the proviso that R.sub.1 is not meta CF.sub.3 when R.sub.2 =R.sub.3 =H, and pharmaceutically non-toxic salts thereof. The compounds of this invention are useful in the treatment of allergic and anaphylatic conditions and motion sickness.

REFERENCES:
patent: 3562277 (1971-02-01), Hansen et al.
patent: 3928358 (1975-12-01), Renth et al.
patent: 3981864 (1976-09-01), Tanaka et al.
patent: 4094980 (1978-01-01), Renth et al.

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