2-(4-Phenylalkanoylpiperazin-1-yl) quinazoline compounds, pharma

Details 2-(4-Phenylalkanoylpiperazin-1-yl) quinazoline compounds, pharma 2-(4-Phenylalkanoylpiperazin-1-yl) quinazoline compounds, pharma

1983-02-11

1984-04-03

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544291, A61K 31505, C07D40304

Patent

active

044407696

ABSTRACT:
4-amino-6,7-dimethoxy-2-(4-phenylalkanoylpiperazin-1-yl) quinazolines having .alpha..sub.1 -adrenergic receptor antagonistic activity. These compounds are useful in the treatment of hypertension.

REFERENCES:
patent: 3511836 (1970-05-01), Hess
patent: 3635979 (1972-01-01), Hess
patent: 3663706 (1972-05-01), Hess
patent: 4092315 (1978-05-01), Bianco
The Journal of Biological Chemistry, vol. 257, No. 24, Issue of 12/25, pp. 15174-15181, 1982.
Proc. Natl. Acad. Sci., U.S.A., vol. 79, pp. 2186-2190, Apr. 1982, Biochemistry.
The Journal of Biological Chemistry, vol. 257, No. 20, Issue of Oct. 25, pp. 12332-12340, 12341-12350, 1982, U.S.A.
Federation Proceedings, Mar. 10, 1982, vol. 41, No. 5, Abstract 7064.

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