2,4-disubstituted derivatives of tetrahydrofuran useful for the

Details 2,4-disubstituted derivatives of tetrahydrofuran useful for the 2,4-disubstituted derivatives of tetrahydrofuran useful for the

1988-10-13

1991-03-05

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546283, 548147, 548204, A61K 3144, C07D40512

Patent

active

049978438

ABSTRACT:
The present invention describes novel 2,4-disubstituted derivatives of tetrahydrofuran, having the formula I ##STR1## wherein: -X- is either an oxygen atom or a covalent single bond; --CH.sub.2 XR.sub.1 group is in the position 2 and --CH.sub.2 OR.sub.2 is in the position 4 of the tetrahydrofuran ring, or --CH.sub.2 XR.sub.1 is in position 4 and --CH.sub.2 OR.sub.2 in position 2; -R.sub.1 represents an alkyl or an alkylaminocarbonyl group; -R.sub.2 represents a group having the formula -Y-(CH.sub.2).sub.n -Q.(A.sup.-).sub.q where -Y- is a covalent single bond, a carbonyl group, a carbonyloxy group or a carbonylamino group; n is an integer 0 to 10; Q is a nitrogen containing heterocycle; q is one when Q is charged or q zero when Q is neutral; and A.sup.- is a pharmaceutically acceptable anion. These compounds are PAF antagonists and, thus, useful for the treatment of diseases in which PAF is involved.

REFERENCES:
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