2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic a

Details 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic a 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic a

1988-07-20

1990-02-13

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544298, 544319, C07D23922

Patent

active

049008293

ABSTRACT:
Disclosed herein are 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic acids and pharmaceutically acceptable salts thereof and methods of their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

REFERENCES:
patent: 4505910 (1985-03-01), Bagli
patent: 4568693 (1986-02-01), Sestanj et al.
patent: 4786638 (1988-11-01), Bagli et al.
D. J. Brown, the Pyrimidines, 1962, pp. 289-291, 359-360.
March, Advanced Organic Chemistry, 3rd Edition, 1985, pp. 334-335.
Kinoshita et al., Biochem. Biophys. Acta 158, 472-475 (1968).
Bubranski et al., CA96-142888b.
Mitsui Toatsu Chemicals, Inc. CA97-110029b.
Vainilavicius et al., CA105-191119q.

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