2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic a

Details 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic a 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic a

1987-06-12

1988-11-22

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514269, 544295, 544319, A61K 31495, A61K 31505, C07D40304, C07D40104

Patent

active

047866381

ABSTRACT:
Disclosed herein are 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic acids and pharmaceutically acceptable salts thereof and methods of their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

REFERENCES:
patent: 4505910 (1985-03-01), Bagli
patent: 4568693 (1986-02-01), Sestanj
patent: 4617393 (1986-10-01), Bagli
Kinoshita et al., Biochem. Biophys. Acta 158(1968) pp. 472-475.
Bobranski et al., CA 96-142888b.
Mitsui Toastsu Chemicals, Inc. CA97-110029b.
Vainilavicuiis et al. CA 105-191119q.

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