Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Reexamination Certificate
2011-03-29
2011-03-29
Saeed, Kamal A (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
C544S121000, C544S129000, C544S133000, C546S209000, C546S270700, C548S192000, C514S232200, C514S235800, C514S236800, C514S253090, C514S254040, C514S326000, C514S369000
Reexamination Certificate
active
07915405
ABSTRACT:
Disclosed herein are 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives, a preparation method thereof, and a therapeutic agent for treating inflammatory diseases induced by SPC, which contains the derivative as an active ingredient. The anti-inflammatory effect of the 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives was analyzed through a test employing human dermal cells and an animal test using mice and, as a result, it was found that the derivatives showed excellent inhibitory activity on SPC receptor compared to thiazole derivatives known in the prior art. Thus, the 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives or pharmaceutically acceptable salts thereof are useful as active ingredients in therapeutic agents for treating inflammatory diseases, such as inflammation, pruritus and skin infection, which appear in atopic dermatitis and other diseases induced by SPC activity.wherein R1, R2, R3and R4are as defined in the specification.
REFERENCES:
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Cho Heeyeong
Choi Gildon
Gong Young-Dae
Hwang Soon-Hee
Jeon Moon-Kook
Grazier Nyeemah
Korea Research Institute of Chemical Technology
Reinhart Boerner Van Deuren P.C.
Saeed Kamal A
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