2,4-disubstituted 1,3-dioxolanes and pharmaceutical use

Details 2,4-disubstituted 1,3-dioxolanes and pharmaceutical use 2,4-disubstituted 1,3-dioxolanes and pharmaceutical use

1988-10-13

1990-07-10

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

548112, 548113, 548178, 548203, 548204, 548205, 548235, 548236, 549221, 549451, 549452, 514 80, 514 82, 514 89, 514 90, 514 92, 514101, 514297, 514314, 514336, 514365, 514367, 514374, 514467, 544148, 546 22, 546 23, 546102, 546104, 546152, 546174, 546175, 546283, A61K 31335, C07D31728, C07D31730

Patent

active

049407066

ABSTRACT:
The present invention describes novel 2,4-disubstituted 1,3-dioxolanes having the formula I ##STR1## wherein R.sup.1 represents a long chain alkyl group; X is a covalent single bond, a carbonyl group, a carboxyl group, a carbamoyl group or a --O--P(.dbd.O)(O.sup.z)-- group; z is a negative charge (-) when q is zero, or z is an hydrogen atom when q is one; n is an integer from 2 to 10; R.sup.2, R.sup.3 and R.sup.4 are lower alkyl groups, or R.sup.2 R.sup.3 R.sup.4 N.sup.+ represents an aromatic cyclic ammonium group or R.sup.2 R.sup.3 R.sup.4 N.sup.+ represents a non-aromatic cyclic ammonium group in which two of the groups (R.sup.2, R.sup.3 or R.sup.4) form a non-aromatic ring together with the quaternary nitrogen atom; and A.sup.- is a pharmaceutically acceptable anion. These compounds are in vitro inhibitors of the platelet aggregation induced by the platelet activating factor (PAF) and, thus, useful for the treatment of the diseases in which this substance is involved. On the other hand, some of these compounds have hypotensive activity without provoking activation of the platelets.

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