2-[4-(Diphenylmethylene)-1-piperidinyl]-acetic acids and their a

Details 2-[4-(Diphenylmethylene)-1-piperidinyl]-acetic acids and their a 2-[4-(Diphenylmethylene)-1-piperidinyl]-acetic acids and their a

1981-09-17

1984-04-17

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546239, 546234, A61K 31445, C07D21122

Patent

active

044434600

ABSTRACT:
New 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acids and their amides, processes for the preparation thereof and therapeutic compositions. These compounds have the formula ##STR1## wherein Y=--OH or --NR.sub.1 R.sub.2, R.sub.1 and R.sub.2 =H, alkyl or phenyl; X=H, halogen or alkoxy; m=0, 1 or 2 and n=1 or 2.
The 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester, whereas the amides are prepared either by reacting a 4-(diphenylmethylene)-piperidine with an omega-haloacetamide, or by reacting an alkali metal salt of an omega-[4-diphenylmethylene)-1-piperidinyl]-alkanol (m=1 or 2) with a 2-haloacetamide, or by reacting a nitrogen compound (HNR.sub.1 R.sub.2) with a halide or alkyl ester of a 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acid.
These compounds have in particular an antiallergic, spasmolytic, antihistaminic and broncholytic activity.

REFERENCES:
patent: 2898339 (1959-08-01), Wheeler et al.
patent: 3576810 (1971-04-01), Duncan et al.
patent: 3687956 (1972-08-01), Zivkovic
patent: 3806526 (1974-04-01), Carr et al.
patent: 3922276 (1975-11-01), Duncan et al.
patent: 4251655 (1981-02-01), Scott et al.
patent: 4285958 (1981-08-01), Carr et al.

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