2,4-diphenyl-1,3-dioxanes

Details 2,4-diphenyl-1,3-dioxanes 2,4-diphenyl-1,3-dioxanes

1986-05-09

1988-10-04

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549375, 549373, A61K 31335, C07D31906

Patent

active

047756853

ABSTRACT:
The invention provides a novel group of 4(Z)-([2,4,5-cis]-2,4-diphenyl-1,3-dioxan-5-yl)hexenoic acids of formula I, wherein X is F, Cl, Br, CF.sub.3, CN, CH.sub.3 O or NO.sub.2 and one of Y and Z is hydrogen or fluoro and the other is hydrogen, and their pharmaceutically acceptable salts; together with their pharmaceutical compositions for use in treating a variety of disease conditions. Also provided are methods for the manufacture of novel compounds. Representative compounds are those in which X is 2-cyano or 2-chloro and Y and Z are both hydrogen.

REFERENCES:
patent: 4567197 (1986-01-01), Brewster et al.

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