2,4-dimethyl-5-oxohexane and a method of use therefor

Details 2,4-dimethyl-5-oxohexane and a method of use therefor 2,4-dimethyl-5-oxohexane and a method of use therefor

1993-07-29

1994-08-02

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

558368, 558440, C07D21309, C07D21312

Patent

active

053347218

ABSTRACT:
The invention relates to a process for the preparation of high yields of 5-oxohexane nitriles with minimum formation of 1 undesired isomer. Such nitriles may be utilized as starting materials for the preparation of pharmaceutical and agrochemical intermediates and as well as final products. The process comprises reacting a methyl ketone and an .alpha.,.beta.-unsaturated nitrile in the presence of a catalytically effective amount of a strong base. One of the products which may be created by the process is 2,4-dimethyl-5-oxohexane nitrile.

REFERENCES:
patent: 2381371 (1945-08-01), Shannon
patent: 2579580 (1951-12-01), Howk et al.
patent: 2850519 (1958-09-01), Krimm
patent: 3007931 (1961-11-01), Simpson et al.
patent: 3816503 (1974-06-01), Von Poelvoorde et al.
patent: 4005227 (1977-01-01), Winter et al.
patent: 4117000 (1978-09-01), Balg et al.
patent: 4245098 (1981-01-01), Steiner et al.
patent: 4267362 (1981-05-01), Meyer et al.
patent: 4276419 (1981-06-01), Verheijen et al.
patent: 4294968 (1981-10-01), Stone et al.
patent: 4386207 (1983-05-01), de Graaf et al.
patent: 4405552 (1983-09-01), Miesel
patent: 4468354 (1984-08-01), Lysenko et al.
patent: 4577028 (1986-03-01), Martin et al.
patent: 4599422 (1986-07-01), Amey
patent: 4665186 (1987-05-01), Steiner et al.
patent: 4897484 (1990-01-01), Weis et al.
patent: 4996323 (1991-02-01), Pews
patent: 5053516 (1991-10-01), Hartmann et al.
Ono, et. al., C.A, 94:120797c (1981).
Ogigin, et. al., C.A., 94:173976s (1981).
Troyanskii, et. al., C.A., 96:103603k (1982).
Levinson, et. al., C.A., 97:92140z (1982).
Fuji, C.A., 99:21958c (1983).
Williams, et. al., C.A. 113:191050a (1990).
Organic Reactions, vol. 5, pp. 130-133, (1949) (in Chapter 2 on "Eyonoethylation"by Breeson).
Ono et. al., "A Novel Synthesis of (+)-Serricornin 4,6-Dimethyl-7-hydroxy-nonan-3-one" The Sex Pheromone of Cigarette Beetle (Lasioderma serricorne F.), Agric. Biol. Chem., 44(9), pp. 2259-2260, (1980).
March, "Advanced Organic Chemistry" Reactions, Mechanisms, and Structure, A Wiley-Interscience Publication by John Wiley & Sons, Third Edition, pp. 16-18, (1971).

Affiliated with

Also associated with

Rating

2,4-dimethyl-5-oxohexane and a method of use therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2,4-dimethyl-5-oxohexane and a method of use therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,4-dimethyl-5-oxohexane and a method of use therefor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-65764