2,4-dimethoxy-4'-hydroxy-benzophenone

Details 2,4-dimethoxy-4'-hydroxy-benzophenone 2,4-dimethoxy-4'-hydroxy-benzophenone

1991-06-20

1992-03-03

Nutter, Nathan M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568333, C07C 4976, C07C 49786

Patent

active

050935305

ABSTRACT:
A synthetic resin based on a polystyrene that can be used as a support for solid phase peptide synthesis and that has been cross-linked with from 0 to 5 mol % of divinyl benzene, characterized in that it has been substituted at benzene rings of its skeletal structure by groups of the formula ##STR1## in which X represents --O-- or --NH-- and R represents C.sub.1 -C.sub.4 -alkyl, as a support renders possible the solid phase synthesis of peptides and peptide amides that are, if desired, protected at the N-terminal and/or at other functional groups. The resin is manufactured by reaction of a customary chloromethylated polystyrene resin with an alkali metal salt of the corresponding 4-hydroxybenzophenone and subsequent reduction of the carbonyl group and, optionally, amination.

REFERENCES:
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patent: 4569967 (1986-02-01), Kornreich et al.
patent: 4623484 (1986-11-01), Carpino et al.
patent: 4731412 (1988-03-01), Kaiser et al.
patent: 4859736 (1989-08-01), Rink
Tetrahedron vol. 27, pp. 2701-2703 (1971).
Preceedings of the 7th American Peptide Symposium, (1981), pp. 163-175.
Tetrahedron Letters vol. 28, No. 33 pp. 3787-3790 (1987).
Peptide Chemistry pp. 279-282 (1987).
Journal of Organic Chemistry vol. 52 No. 7 (1987) pp. 1196-1200.
Tetrahedron Letters vol. 28 No. 46 pp. 5651-5654 (1987).
Indian Journal of Chemistry vol. 9 (1971) pp. 619-623.

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