Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1983-04-29
1986-05-20
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
514252, 514255, 514275, 514326, 544114, 544295, 544325, 548465, 548503, 549 49, 549 58, 549462, 549467, C07D23949, C07D40106, C07D40506, A61K 31505
Patent
active
045902712
ABSTRACT:
Compounds of the formula (II) ##STR1## or a salt, N-oxide or acyl derivative thereof, wherein Y is a group ##STR2## which is linked to the pyrimidinylmethyl moiety at the 1 or 7-position and is optionally substituted at the 2, 3, 4 or 6-position or at the 7-position when the linkage to the pyrimidinylmethyl moiety is at the 1-position wherein X is an oxygen or sulphur atom, a group CH.sub.2, a group S(O).sub.n where n=1 or 2, a group NR.sup.1 wherein R.sup.1 is hydrogen C.sub.1-4 alkyl or a group COR.sup.2 where R.sup.2 is hydrogen, C.sub.1-4 alkoxy or amino and the dotted line represents a single or double bond, have antimicrobial activity. Processes for making these compounds, pharmaceutical compositions containing them and the medical use of the compounds are also disclosed.
REFERENCES:
patent: 3819629 (1974-06-01), Roth et al.
patent: 4039543 (1977-08-01), Kompis et al.
patent: 4438267 (1984-03-01), Daluge et al.
Mazurczak, Chemical Abstract, vol. 89, pp. 656-657, 24352e (1978).
Daluge, Chem. Abst., vol. 97, 1982, pp. 729, 730, 127652x, equi. to UK 2087881.
Daluge Susan M.
Rauckman Barbara S.
Roth Barbara
Skonezny Paul M.
Brown Donald
Burroughs Wellcome Co.
Daus Donald G.
Shen Cecilia
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