2,4-Diamino-5-alkyloxy-pyrimidines

Details 2,4-Diamino-5-alkyloxy-pyrimidines 2,4-Diamino-5-alkyloxy-pyrimidines

1977-07-14

1979-12-18

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424251, C07D23948

Patent

active

041795628

ABSTRACT:
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof and antimalarial and antibacterial compositions containing an effective amount of active agent and a pharmaceutically acceptable carrier particularly in oral dosage form wherein R is hydrogen, methyl or ethyl; X is alkylene of 1-10 carbon atoms; Y is oxygen, sulphur or a bond, and Ar is an optionally substituted aryl moiety; are useful for their antimalarial and antibacterial activity.

REFERENCES:
patent: 3105074 (1963-09-01), Mamalis
patent: 3723429 (1973-03-01), Mamalis et al.
Falco et al., J. Amer. Chem. Soc. 73 (1951), pp. 3753-3758.
Burger, Medicinal Chemistry, 3rd Ed., (1970) pub. by Wiley-Interscience, pp. 479-502.

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