2,4-diamino-5[4-amino (or dimethylamino)-3,5-dimethoxybenzyl]pyr

Details 2,4-diamino-5[4-amino (or dimethylamino)-3,5-dimethoxybenzyl]pyr 2,4-diamino-5[4-amino (or dimethylamino)-3,5-dimethoxybenzyl]pyr

1987-01-14

1988-12-20

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544324, 544325, A61K 31505

Patent

active

047925574

ABSTRACT:
2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.

REFERENCES:
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patent: 3715357 (1973-02-01), Rey-Bellet et al.
patent: 3772289 (1973-11-01), Roth
patent: 3819629 (1974-06-01), Roth et al.
patent: 3822264 (1974-07-01), Roth
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patent: 4039543 (1977-08-01), Kompis et al.
patent: 4203980 (1980-05-01), Kompis et al.
Roth et al., J. Med. Pharm. Chem. 5 1962, pp. 1103-1122.
Falco JACS, vol. 73, p. 3758.

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