2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)

Details 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl) 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)

1981-06-30

1985-05-07

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23948

Patent

active

045159483

ABSTRACT:
2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.

REFERENCES:
patent: 2670351 (1954-02-01), Jacob
patent: 3692787 (1982-09-01), Roth et al.
Roth J. Med. Pharm. Chem. 5, (1962), pp. 1103-1125.
Falco et al., JACS vol. 23, pp. 3258-3262, (1951).

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