Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1984-04-09
1986-05-20
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544323, 544325, 514272, 514275, 546210, A61K 31505, C07D40104, C07D45102
Patent
active
045902704
ABSTRACT:
The pyrimidine derivatives of formula I ##STR1## wherein R.sup.1 is naphthyl, substituted naphthyl or substituted phenyl; R.sup.2 is hydrogen or lower alkoxy; and A is an optionally present ethylene or 1,3-propylene, and wherein the diaminopyridine group has the exo-configuration when A is present,
are described. These compounds are useful as antibacterial agents, antimalarial agents and antitumor agents, and can be used in combination with sulfonamides in the control of bacterial infections.
REFERENCES:
patent: 3133073 (1964-05-01), Archer
patent: 4053475 (1977-10-01), Lesher et al.
patent: 4109092 (1978-08-01), Lesher et al.
patent: 4438267 (1984-03-01), Daluge et al.
Henrietta Bull, Physicians' Desk Reference (1960) 15th edition, p. 809, Aralen Phosphate.
Burger, Medicinal Chemistry, 2nd edition (1960) p. 42.
Kompis et al, Chem. Abst. 88-152540f.
Sterling Drug Inc., Chem. Abst. 51-15607c; Brit. 762256.
Lesher et al, Chem. Abst. 86-29868a; Ger. Offen. 2609208.
Kompis Ivan
Locher Rita
Maag Hans
Boxer Matthew
Daus Donald G.
Hoffmann-La Roche Inc.
Leon Bernard S.
Saxe Jon S.
LandOfFree
2,4-diamino-[4-piperidinyl]pyrimidines useful as antibacterial a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2,4-diamino-[4-piperidinyl]pyrimidines useful as antibacterial a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,4-diamino-[4-piperidinyl]pyrimidines useful as antibacterial a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2109479