2,4-diamino-1,3,5-triazine derivatives

Details 2,4-diamino-1,3,5-triazine derivatives 2,4-diamino-1,3,5-triazine derivatives

2003-12-16

2009-11-24

Richter, Johann R (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S241000, C514S246000, C514S311000, C544S204000, C544S208000, C544S209000

Reexamination Certificate

active

07622469

ABSTRACT:
The present invention relates to an antibacterial agent, which comprises, as an active ingredient, a compound represented by the following general formula (1):or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 3168519 (1965-02-01), Nagy
patent: 3287365 (1966-11-01), Newman et al.
patent: 3287366 (1966-11-01), Newman et al.
patent: 3563988 (1971-02-01), Feichtinger et al.
patent: 5565451 (1996-10-01), Peake et al.
patent: 7034021 (2006-04-01), Moinet et al.
patent: 2003/0109530 (2003-06-01), Moinet et al.
patent: 45-41591 (1970-12-01), None
patent: 99/01442 (1999-01-01), None
patent: 00/32580 (2000-06-01), None
patent: 01/055122 (2001-08-01), None
patent: WO 01/55122 (2001-08-01), None
patent: 2004/087153 (2004-10-01), None
Edward J. Modest and Philip Levine, “Chemical and Biological Studies on 1,2-Dihyrdo-s-triazines. III. Two-Component Synthesis”, Journal of Organic Chemistry, 1956, 21(1), 14-20.
H.C. Carrington, A.F. Crowther, D.G. Davey, A.A. Levi, and F.L. Rose, “A Metabolite of ‘Paludrine’ with High Antimalarial Activity”, Nature, 1951, 168, 1080.
R. J. A. Walsh et al., “The Structure Activity Relationship of Antibacterial Substituted 1-Phenyl-4,6-Diamino-1,2-Dihydro-2,2-Dimethyl-s-triazines”, Eur. J. Med. Chem., vol. 12, No. 6, pp. 495-500, Nov.-Dec. 1977.
M. S. Bartlett et al., “Evaluation of Potent Inhibitors of Dihydrofolate Reductase in a Culture Model for Growth ofPneumocystis carinii”, Antimicrobial Agents and Chemotherapy, pp. 2436-2441, vol. 39, No. 11, Nov. 1995.
L. Chio et al., “Identification of Highly Potent and Selective Inhibitors ofToxoplasma gondiiDihydrofolate Reductase”, Antimicrobial Agents and Chemotherapy, vol. 37, No. 9, pp. 1914-1923, Sep. 1993.
H. M. Eisa et al., “Synthesis of certain 2-aminoadamantane derivatives as potential antimicrobial agents”, Pharmazie, vol. 46, No. 3, pp. 182-184, 1991.
H. M. Eisa et al., “Synthesis and Antimicrobial Testing of 2-Amino-4- (p-Fluro-m-Nitroanilino)-6-Substituted-s-Triazines”, Pakistan J. Sci. Ind. Res., vol. 31, No. 7, pp. 474-478, Jul. 1988.
E. A. Coats et al., “Quantitative Structure-Activity Relationship of Antifolate Inhibition of Bacteria Cell Cultures Resistant and Sensitive to Methotrexate”, J. Med. Chem. vol. 28, No. 12, pp. 1910-1916, 1985.
B. Testa et al., “Steric and Lipophobic Components of the Hydrophobic Fragmental Constant”, Drug Res., vol. 31, No. 7, pp. 1053-1058, 1981.
C. S. Genther et al., “Antifolate Studies. Activities of 40 Potential Antimalarial Compounds against Sensitive and Chlorguanide Triazine Resistant Strains of Folate-Requiring Bacteria andEscherichia coi”, Journal of Medicinal Chemistry, vol. 20, No. 2, pp. 237-243, 1977.
B. R. Baker, “Differential Binding to the Hydrophobic Bonding Region of T2Phage Induced,Escherichia coliB, and Pigeon Liver Dihydrofolic Reductases1,2”, Journal of Medicinal Chemistry, vol. 10, No. 5, pp. 912-917, Sep. 1967.
T. Seo et al., “Syntheses and Properties of Polyguanamine from Diester and Bisbiguanide”, Nippon Kagaku Kaishi, No. 12, pp. 2419-2424, 1974, in Japanese language with English abstract.
A. Rosowsky et al., “Structure-Activity and Structure-Selectivity Studies on Diaminoquinazolines and other Inhibitors ofPneumocystis cariniiandToxoplasma gondiiDihydrofolate Reductase”, Antimicrobial Agents and Chemotherapy, vol. 39, No. 1, pp. 79-86, Jan. 1995.
W. R. Turner et al., “Novel Bis[1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamines] as Antitrypanosomal Agents1,2”, J. Med. Chem., vol. 28, No. 11, pp. 1728-1740, 1985.
Partial Supplementary European Search Report issued Sep. 25, 2007 in the European Application No. 03780808.6-1211, PCT/JP0316131, of which the present application in the U.S. National Stage.
Foley, G.E. et al., “A Comparative Study of the Use of Microoraganisms in the Screening of Potential Antitumor Agents”, Annals of The New York Academy of Science, New York, NY, US, vol. 76, No. 3, pp. 413-441.

Affiliated with

Also associated with

Rating

2,4-diamino-1,3,5-triazine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2,4-diamino-1,3,5-triazine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,4-diamino-1,3,5-triazine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4076910