Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-05-29
2007-05-29
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S360000, C544S364000, C544S370000, C546S296000
Reexamination Certificate
active
10883710
ABSTRACT:
The present invention is directed to a 2,4-bis(trifluoroethoxy)pyridine compound represented by formula (1):(wherein X1represents a fluorine atom or a hydrogen atom) or a salt thereof, and to a drug containing the compound or the salt as an active ingredient.The compound has metabolic resistance in human liver microsome, good absorbability upon oral administration, and excellent ACAT inhibitory activity.
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patent: 2004/052861 (2004-06-01), None
patent: WO 98/54153 (1998-12-01), None
Peter J. Gillies, et al., “Regulation of Acyl-CoA: Cholesterol Acyltransferase Activity in Normal and Atherosclerotic Rabbit Aortas: Role of a Cholesterol Substrate Pool”, Experimental and Molecular Pathology, vol. 44, 1986, pp. 329-339.
Lei Li, et al., “Effects of high-density lipoprotein2on cholesterol transport and acyl-coenzyme A:cholesterol acyltransferase activity in P388D1 macrophages”, Biochimica et Biophysica Acta, vol. 1530, No. 1, 2001, pp. 111-122.
U.S. Appl. No. 10/498,984, filed Jun. 25, 2004, Shibuya, et al.
U.S. Appl. No. 10/558,197, filed Nov. 25, 2005, Shibuya, et al.
Matsuda Takayuki
Miura Toru
Ohgiya Tadaaki
Shibuya Kimiyuki
Bernhardt Emily
Kowa Co. Ltd.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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