2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii ag

Details 2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii ag 2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii ag

1998-02-27

1999-12-28

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514473, 5483154, 549495, 549497, 549504, 549506, A61K 3134, C07D23306, C07D30708

Patent

active

06008247&

ABSTRACT:
Compounds according to the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; and X and Y are located in the para or meta positions and are each selected from the group consisting of H, loweralkyl, oxyalkyl, and ##STR2## wherein: each R.sub.5 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.5 groups together represent C.sub.2 to C.sub.10 alkyl, hydroxyalkyl, or alkylene; and R.sub.6 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylamino, lkylarninoalkyl, cycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, aryl, or alkylaryl; or a pharmaceutically acceptable salt thereof, are disclosed. The compounds are useful for treating Pneumocystis carinii in a subject in need of such treatment.

REFERENCES:
patent: 3359284 (1967-12-01), Patai et al.
patent: 3470151 (1969-09-01), Doyle et al.
patent: 5521189 (1996-05-01), Boykin et al.
patent: 5602172 (1997-02-01), Boykin et al.
patent: 5667975 (1997-09-01), Dykstra et al.

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