2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii ag

Details 2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii ag 2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii ag

1999-05-14

2000-10-03

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30738

Patent

active

061275549

ABSTRACT:
Compounds according to the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; and X and Y are located in the para or meta positions and are each selected from the group consisting of H, loweralkyl, oxyalkyl, and ##STR2## wherein: each R.sub.5 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.5 groups together represent C.sub.2 to C.sub.10 alkyl, hydroxyalkyl, or alkylene; and R.sub.6 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylamino, lkylaminoalkyl, cycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, aryl, or alkylaryl; or a pharmaceutically acceptable salt thereof, are disclosed. The compounds are useful for treating Pneumocystis carinii in a subject in need of such treatment.

REFERENCES:
patent: 3359284 (1967-12-01), Patai et al.
patent: 3470151 (1969-09-01), Doyle et al.
patent: 5521189 (1996-05-01), Boykin et al.
patent: 5602172 (1997-02-01), Boykin et al.
patent: 5667975 (1997-09-01), Dykstra et al.
Padmanabhan et al., Bull. Chem. Soc. Jpn., 62(6), pp. 2114-2116, 1989.

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