2-(4-benzoyl-1-piperidyl)-1-phenylalkanol derivatives

Details 2-(4-benzoyl-1-piperidyl)-1-phenylalkanol derivatives 2-(4-benzoyl-1-piperidyl)-1-phenylalkanol derivatives

1986-05-13

1987-12-08

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546225, A61K 31445, C07D21132

Patent

active

047118997

ABSTRACT:
Compound of general formula I ##STR1## in which R is hydrogen, R.sub.1 is unsubstituted phenyl, 4-methoxy - 3,5-dimethylphenyl or phenyl substituted at one of the 2-, 3- or 4- positions by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, hydroxy, benzyloxy, trifluoromethyl, cyano, nitro, amino, acetylamino, methylthio, methylsulphonyl or aminosulphonyl and R.sub.2 is unsubstituted phenyl, 2,4,6-trimethoxyphenyl or phenyl substituted at either the 3- or the 4- positions by fluorine, chlorine, methyl or methoxy, or an acid addition salt thereof.

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Duncan, Jr., et al.; Journal of Med. Chem. 13, Jan. 1970; pp. 1-6.
Weygand/Hilgetag; "Preparative Organic Chemistry", (1972) p. 535; John Wiley & Sons, N.Y. & London.
Noller, "Chemistry of Organic Compounds, (1965), 3rd ed., pp. 257-258, 813-814; W. B. Saunders Co., Phila. & London.

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